Publications

Fields of research: biochemistry and cell biology, neurodegenerative diseases, clinical sciences, neuroscience, medical physiology and epidemiology.

Long-read transcriptomic identification of synaptic adaptation to amyloid pathology in the AppNL-G-F knock-in mouse model of the earliest phase of Alzheimer’s disease

Authors: Umran Yaman, Gareth Banks, Emil K. Gustavsson, Paige Mumford, Naciye Magusali, Orjona Stella Taso, Hannah Macpherson, Susana Carmona, Malgorzata Murray, Rasneer Sonia Bains, Hamish Forrest, Michelle Stewart, Connor Scott, Tatiana V. Lipina, Zhao Cheng, Anna L. Tierney, Richard D. Unwin, Juan A. Botia, Carlo Sala Frigerio, Sara E. Wells, John Hardy, Lilach Soreq, Frances K. Wiseman, Dervis A. Salih

Date: 10 Aug 2024

Microglia produce the amyloidogenic ABri peptide in familial British dementia.

Authors: Arber C, Casey JM, Crawford S, Rambarack N, Yaman U, Wiethoff S, Augustin E, Piers TM, Rostagno A, Ghiso J, Lewis PA, Revesz T, Hardy J, Pocock JM, Houlden H, Schott JM, Salih DA, Lashley T, Wray S

Date: 28 Jun 2023

Genetic variation associated with human longevity and Alzheimer's disease risk act through microglia and oligodendrocyte cross-talk

Authors: Graham A, Bellou E, Harwood J, Yaman U, Celikag M, Magusali N, Rambarack N, Botia J, Frigerio CS, Hardy J, Escott-Price V, Salih D

Date: 3 Apr 2023

A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene

Authors: Magusali N, Graham AC, Piers TM, Panichnantakul P, Yaman U, Shoai M, Reynolds RH, Botia JA, Brookes KJ, Guetta-Baranes T, Bellou E, Bayram S, Sokolova D, Ryten M, Sala Frigerio C, Escott-Price V, Morgan K, Pocock JM, Hardy J, Salih DA

Date: 7 Oct 2021

Journal: Brain

Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia

Authors: Benitez DP, Jiang S, Wood J, Wang R, Hall CM, Peerboom C, Wong N, Stringer KM, Vitanova KS, Smith VC, Joshi D, Saito T, Saido TC, Hardy J, Hanrieder J, De Strooper B, Salih DA, Tripathi T, Edwards FA, Cummings DM

Date: 15 Jul 2021

Journal: Molecular Neurodegeneration

TREM2-mediated activation of microglia breaks link between amyloid and tau

Authors: Hardy J, Salih D

Date: 1 Jun 2021

Journal: Lancet Neurology

Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD - a multi-modal and multi-centre study

Authors: Chaney AM, Lopez-Picon FR, Serrière S, Wang R, Bochicchio D, Webb SD, Vandesquille M, Harte MK, Georgiadou C, Lawrence C, Busson J, Vercouillie J, Tauber C, Buron F, Routier S, Reekie T, Snellman A, Kassiou M, Rokka J, Davies KE, Rinne JO, Salih DA, Edwards FA, Orton LD, Williams SR, Chalon S, Boutin H

Date: 19 Apr 2021

Journal: Theranostics